"Our study results demonstrate the high prevalence of financial toxicity for MS patients and the resulting decisions patients make that impact their health care and lifestyle," said study author Dr. Gelareh Sadigh, an assistant radiology professor at Emory University School of Medicine in Atlanta.
The study, sponsored by the Harvey L. Neiman Health Policy Institute in Reston, Va., is the first to evaluate "financial toxicity" in MS patients and whether financial hardship is associated with forgoing medication and imaging follow-up prescribed in their treatment plan, the authors said.
MS patients can face considerable financial struggles due to expensive treatments, high rates of disability and lost income.
"Over the last 20 years, higher out-of-pocket costs for advanced imaging tests and increased cost sharing have caused the financial burdens on MS patients to escalate.
"In addition to the impact on adherence, financial toxicity was associated with significantly lower physical health-related quality of life, demonstrating the broad consequences of treatment costs for many MS patients," added Duszak, vice chair for health policy and practice in the Department of Radiology and Imaging Sciences at Emory.
She argued that the birds could be impacted by unseasonable cold weather and early snowfall but said southern New Mexico temperatures should not be cold enough to kill the animals.
The New Mexico Wildlife Center in Espanola confirmed Monday that the state Department of Game and Fish would collect bird carcasses from their facility for laboratory analysis.
Biologists from the university and White Sands Missile Range examined about 300 carcasses last week gathered in the region, but further observations could place casualties in the hundreds of thousands, “if not millions,” Desmond said.
Professor Martha Desmond said Monday that reports from around the state indicate migratory species are dying at unprecedented numbers, which could be caused by multiple conditions from drought to wildfires, the Las Cruces Sun-News reported.
LAS CRUCES, N.M. (AP) - Researchers at New Mexico State University in Las Cruces have invited residents to share photos or written descriptions via their cellphones involving a recent mass die-off of migratory birds in the state.
She had long been working on applying CRISPR to diagnostics via her lab at Berkeley, as well as companies she co-founded, Caribou Biosciences and Mammoth Biosciences — with the latter now developing a COVID test.
The test Mammoth has created uses CRISPR technology, but rather than programming a protein to find a bit of gene to cut out, it detects it.
There’s another benefit to developing CRISPR diagnostics: Doudna says that if a Sars-Cov-2 test works, it should work on other viruses, meaning all the frantic effort to create these diagnostic tools will be of benefit in the next pandemic, whenever it lands.
Researchers at Stanford University were working on ways to use CRISPR to fight influenza, but pivoted to coronavirus when the pandemic hit, pairing a virus-killing enzyme with guide RNA in an effort to meddle with genetic code in SARS-COV-2, in the hopes of preventing it from replicating.
For Covid-19, the faster pace of CRISPR diagnostic development and regulatory approval could give us at-home tests that don’t need to be sent away to the lab — giving us an answer in minutes if we’re infected, letting us get back to work, travel, and whatever else we’re missing in lockdown.
In the latest scientific triumph to offer new insights into the immune system's response to the coronavirus that's on the cusp of sickening more than 30 million people worldwide, a team at the University of Pittsburgh has successfully isolated an "antibody component" to the virus in a breakthrough that, scientists say, could be used in a new therapeutic.
According to the release, the antibody component, which is 10x smaller than a full-sized antibody, has been used to construct a drug - known as Ab8 - that will potentially be use as a therapeutic and prophylactic against the virus.
In the abstract, the scientists said that the "Bivalent V-sub-H" showed a "high affinity" to bind to the cells of hamsters, preventing them from infection with SARS-CoV-2.
“Ab8 not only has potential as therapy for COVID-19, but it also could be used to keep people from getting SARS-CoV-2 infections,” said co-author John Mellors, chief of the Division of Infectious Diseases at Pitt and UPMC.
“Antibodies of larger size have worked against other infectious diseases and have been well tolerated, giving us hope that it could be an effective treatment for patients with COVID-19 and for protection of those who have never had the infection and are not immune.”
Fossils and DNA suggest people looking like us, anatomically modern Homo sapiens, evolved around 300,000 years ago.
Surprisingly, archaeology – tools, artifacts, cave art – suggest that complex technology and cultures, “behavioral modernity,” evolved more recently: 50,000-65,000 years ago.
For 200,000-300,000 years after Homo sapiens first appeared, tools and artifacts remained surprisingly simple, little better than Neanderthal technology, and simpler than those of modern hunter-gatherers such as certain indigenous Americans.
This sudden flourishing of technology is called the “great leap forward,” supposedly reflecting the evolution of a fully modern human brain.
Numbers drove culture, culture increased numbers, accelerating cultural evolution, on and on, ultimately pushing human populations to outstrip their ecosystems, devastating the megafauna, and forcing the evolution of farming.
The damage came into clearer view when Doble imaged the retinas with his device, called an adaptive optics-optical coherence tomography-scanning laser ophthalmoscope: The two lesions in the right eye and one in the left eye appear as black gaps in a sea of individual cells.
One of the main research goals in Doble's lab is to utilize such high-resolution imaging systems to detect and monitor various eye diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma.
Only with the optical scanning system, engineered by Nathan Doble, associate professor of optometry at Ohio State, could scientists count individual cells to see precisely what had happened to the teen's eyes.
His minimal vision loss tells some of the story, but a high-resolution optical imaging device developed by Ohio State University researchers showed in stark detail that cells in the boy's retinas are missing—"blasted away" by the laser, his ophthalmologist explained.
High-resolution image of lesions A and E and 3 smaller areas of cone loss (lesions B, C and D) in the right eye.
Why It Matters: Pfizer CEO Albert Bourla said the company’s vaccine, made in partnership with BioNTech SE (NASDAQ: BNTX), could be distributed in the U.S. before the year-end, if found safe, CNBC noted.
“The only vaccine that if everything went perfectly, might seek the emergency use license by the end of October, would be Pfizer,” Gates said.
Microsoft Corporation (NASDAQ: MSFT) co-founder Bill Gates, whose foundation has donated millions to Pfizer for the development of a COVID-19 vaccine, and is also supporting efforts of other life science companies, thinks none of the vaccines are likely to seek approval in the U.S. before October, CNBC reported.
Pfizer Inc (NYSE: PFE) on Tuesday said only mild-to-moderate side effects were observed in volunteers administered with its COVID-19 vaccine in late-stage human trials.
These vaccines are thought to be the candidates of Moderna Inc (NASDAQ: MRNA) and Pfizer, according to the New York Times.
In regard to this recent recombination scenario, the animal reservoir could not be bats because the ACE2 proteins in bats are not homologous enough to hACE2 and therefore the adaption would not be able to yield an RBM sequence as seen in SARS-CoV-2.
Which leaves just one option: Only one other possibility of natural evolution remains, which is that the ZC45/ZXC21-like virus and a coronavirus containing a SARS-like RBM could have recombined in an intermediate host where the ACE2 protein is homologous to hACE2.
Finally, an in silico study, while echoing the notion that pangolins are not likely an intermediate host, also indicated that none of the animal ACE2 proteins examined in their study exhibited more favorable binding potential to the SARS-CoV-2 Spike protein than hACE2 did.
In 2008, Dr. Zhengli Shi’s group swapped a SARS RBM into the Spike proteins of several SARS-like bat coronaviruses after introducing a restriction site into a codon-optimized spike gene (Figure 5C).
Furthermore, in a recent publication, the RBM of SARS-CoV-2 was swapped into the receptor-binding domain (RBD) of SARSCoV, resulting in a chimeric RBD fully functional in binding hACE2 (Figure 5C)39.
Overt harassment and subtle intimidation during fieldwork compound the discrimination that Black scientists and those from other underrepresented racial and ethnic backgrounds already feel in academic settings.
A National Science Foundation survey found that in 2016, scholars who identified as Black or African American were awarded just 6% of all doctorates in life sciences, and less than 3% of doctorates in physical and Earth sciences.
Many researchers say that exposing middle school and high school students to scientists from diverse backgrounds is essential to combating systemic racism.
Itumeleng Moroenyane, a doctoral student at the National Institute of Scientific Research in Quebec, grew up in post-apartheid South Africa and said he was the only Black botany student in his university’s graduating class.
The University of Washington’s Schell noted that Black scientists have led the field of urban ecology to examine crucial questions about how redlining — racial discrimination in mortgage-lending practices — has shaped urban landscapes, influencing which neighborhoods have more or less green space and biodiversity.
And here's a crucial excerpt from their paper shared by Slashdot reader Hmmmmmm: In addition to the Intel Whiskey Lake CPU in our evaluation, we confirmed similar results on Intel Xeon E3-1505M v5, XeonE3-1270 v6 and Core i9-9900K CPUs, based on the Skylake, KabyLake and Coffee Lake microarchitectures, respectively, as well as on AMD Ryzen 7 2700X and Ryzen 7 3700X CPUs, which are based on the Zen+ and Zen2 microarchitectures.
From a single buffer overflow in the kernel, researchers claim three BlindSide exploits in being able to break KASLR (Kernel Address Space Layout Randomization), break arbitrary randomization schemes, and even break fine-grained randomization.
This works even in face of strong randomization schemes, e.g., the recent FGKASLR or fine-grained schemes based on execute-only memory, and state-of-the-art mitigations against Spectre and other transient execution attacks."
"Security researchers from Amsterdam have publicly detailed 'BlindSide' as a new speculative execution attack vector for both Intel and AMD processors," reports Phoronix: BlindSide is self-described as being able to "mount BROP-style attacks in the speculative execution domain to repeatedly probe and derandomize the kernel address space, craft arbitrary memory read gadgets, and enable reliable exploitation.
Overall, our results confirm speculative probing is effective on a modern Linux system on different microarchitectures, hardened with the latest mitigations.
Allen-Sutter and co-authors Emily Garhart, Kurt Leinenweber and Dan Shim of ASU, with Vitali Prakapenka and Eran Greenberg of the University of Chicago, hypothesized that these carbon-rich exoplanets could convert to diamond and silicate, if water (which is abundant in the universe) were present, creating a diamond-rich and X-rays To test this hypothesis, the research team needed to mimic the interior of carbide exoplanets using high heat and high pressure.
A star with a lower carbon to oxygen ratio will have planets like Earth, comprised of silicates and oxides with a very small diamond content (Earth's diamond content is about 0.001%).
In a new study published recently in The Planetary Science Journal, a team of researchers from Arizona State University (ASU) and the University of Chicago have determined that some carbon-rich exoplanets, given the right circumstances, could be made of diamonds and silica.
As missions like NASA's Hubble Space Telescope, TESS and Kepler continue to provide insights into the properties of exoplanets (planets around other stars), scientists are increasingly able to piece together what these planets look like, what they are made of, and if they could be habitable or even inhabited.
Planetary scientists and astrobiologists are using sophisticated instruments in space and on Earth to find planets with the right properties and the right location around their stars where life could exist.
Gilead Sciences (NASDAQ:GILD) is close to a deal to buy Immunomedics (NASDAQ:IMMU) and its prized Trodelvy breast cancer drug for more than $20B, with an announcement expected by Monday or sooner, WSJ reports.
The acquisition would come at a hefty premium, even after a recent surge in its stock has lifted Immunomedics' market value to ~$10B.
In April, Trodelvy was approved in the U.S. to treat triple-negative breast cancer, an aggressive form of the disease that has spread to other parts of the body.
Trodelvy has shown signs of success in treating lung and other cancers too, and Immunomedics is expected to present data on the drug's performance against bladder cancer at a medical conference this coming week.
CannaGlobal Enters Psychedelics Market Via Merger Cannabis company CannaGlobal Canada Co. announced the definitive closing of a merger with psychedelics companies Sansero Life Sciences and Rise Wellness, giving birth to CannaGlobal Wellness.
On Thursday, the company also announced that its wholly owned subsidiary, HAVN Research Inc., was granted a Section 56 exemption by Health Canada.
Formed in June of 2020, Havn defines itself as a biotechnology company focused on “unlocking human potential using evidence-informed research, and developing standardized psychoactive compounds derived from plants and fungi.”
Havn Life Goes Public on CSE and Announces Authorization for Research Havn Life Sciences Inc. (CSE : HAVN), a recently-formed psychedelics company, announced on Tuesday its debut on the Canadian Securities Exchange under the symbol HAVN.
Steve Sadoff, co-founder of Sansero, Canadian psilocybin research company, will serve as CEO.
[I]n a new study published in the journal Science , researchers have analyzed the chemical elements in thousands of foram samples and found that Earth is barreling toward a hothouse state not seen in 50 million years .
A new study authored by the Germany-based IZA Institute of Labor Economics says the most recent Sturgis Motorcycle Rally, held every summer in South Dakota, was a “superspreading” event.
The study wildly claims the Sturgis event is linked to over 250,000 coronavirus cases across the U.S. and is responsible for an estimated $12.2 billion in public health costs.
South Dakota Governor Kristi Noem and public health officials were quick to debunk the study’s wild claims about Sturgis.
Secretary of Health Kim Malsam-Rysdon questioned the study’s use of cellphone data to track case trends, saying “I don’t think we’ve seen that kind of link proven before.”
South Dakota’s Department of Health has reportedly tracked 124 COVID-19 cases ‘directly linked’ to Sturgis within its state; however, there’s been no indication of how contagious those people actually are since positive test results reported do not disclose their levels of viral load.
PG&E’s computer vision is now analyzing images and identifying approach paths, which the utility says reduces inspection time from about 80 to 52 minutes per structure.
PG&E, which has been using drones for some time, last year began using computer vision to enhance remote aerial inspections of transmission equipment in high risk-fire areas.
PG&E, the state’s largest utility, has been using analytics and machine-learning models to predict how its transmission equipment will handle high-wind events, allowing its operations staff to give priority to maintenance work and even shut power to an area if necessary during severe weather conditions, said Mr. Glass.
Now PG&E and other major California utilities are exploring how AI and other technologies might reduce the risk that damaged gear could start fires.
Edison International’s Southern California Edison is conducting a pilot project using computer vision and machine-learning to inspect distribution and transmission lines in high-risk fire areas, or about 27% of the 50,000 square miles the utility covers.
intelligent vehicle cockpit and wireless communication network concept getty The report, the result of more than 3,000 interviews around the world, said 44% of drivers don’t actually have any “connected services”, and only 51% that do are frequent users.
The report’s author, Rainer Mehl, managing director, Manufacturing, Automotive, Life Sciences at Capgemini Invent, said Tesla has the advantage in delivering connected services now, but it’s not too late for major auto manufacturers.
The only big carmaker to handle connectivity in a user friendly and intelligent way is Tesla TSLA Inc, and it has the advantage of selling its vehicles to first adopters of expensive, high technology likely to be keen to explore the nuances of hands-free driving, radar cruise control, driverless parking, driver coaching and even some over-complicated ways of finding radio stations.
The trouble is, these new technologies will soon become vital parts of driving our vehicles but the big auto manufacturers have done a poor job of underlining their usefulness or making them easy to use.
Automotive manufacturers must move quickly to capture their share of this growth, which will give them access to data they can monetize to reduce costs, optimize RD, introduce new products and services, and limit emissions,” the report said.
For Lawrence Reardon, a professor of political science at the University of New Hampshire who studies China-Vatican ties, restoring relations with the Vatican would be a propaganda coup for China.
For its part, the Vatican seeks more protection and a degree of legitimacy for an estimated 12 million Catholics in China that are currently divided between a state-run authority where the government names the bishops and an “underground” church loyal to the pope.
“China wants to talk to the Vatican because it realizes the Vatican is a soft superpower -- when the Pope speaks, everyone listens,” said Francesco Sisci, a senior researcher at the Renmin University in Beijing.
So any rapprochement with Beijing is sensitive, especially since China’s ultimate goal would be for the Vatican to cut ties with Taiwan.
Wang said at the time that China is “willing to further enhance understanding with the Vatican side.”