Gut microbiome translates stress into sickle cell crises
published 30.07.2020 17:06
"Importantly, we found we could markedly reduce stress-induced VOE in mice through several different interventions: inhibiting the synthesis of glucocorticoids, depleting SFB, or blocking the inflammatory molecules induced by these bacteria," Dr. Frenette said.
"Healthy mice don't have sickled blood cells and therefore don't suffer the ill effects caused by the buildup of aged neutrophils," Dr. Frenette noted.
This greater permeability allows segmented filamentous bacteria (SFB)—a type of beneficial gut bacteria in mice—to interact with Th17 helper immune cells in the lining of the gut.
"Research for sickle-cell disease is chronically underfunded and those with the condition are in need—and deserve—new treatments that can help address this major health disparity," said study leader Paul S. Frenette, M.D., professor of medicine and of cell biology and chair and director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Einstein.
Credit: CC0 Public Domain A new study shows how chronic psychological stress leads to painful vessel-clogging episodes—the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations.